The Recombinant PDK1 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C241245) against PDK1. Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Mouse samples.
This antibody is suitable for IHC and IF applications. It has been validated by IHC analysis of Human liver, Human liver cancer and IF analysis of NIH3T3. The target is localized to the mitochondrion.
Product Name:
Recombinant PDK1 Monoclonal Antibody
SKU:
AGEL6550
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
PDHK, PDHK1, PDK, PDK1
Reactivity:
Human, Mouse
Immunogen:
Recombinant human PDK1 fragment
Applications:
IHCIF
Clonality:
Recombinant Monoclonal
Clone No:
C241245
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
PDK1
Conjugation:
Unconjugated
Recommended Dilution:
IHC 1:100; IF 1:50
UniProt:
Q15118
Purification:
Protein A
Concentration:
1 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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