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Recombinant Phospho-CDK1, 2 (Thr14) Monoclonal Antibody (AGEL6076)

Datasheet MSDS
SKU AGEL6076
Product Type Antibody
Reactivity Human, Mouse, Rat
Applications WB, IHC, IF, IP, ELISA
Host Species Rabbit
Clonality Monoclonal
Clone C110768
Conjugate Unconjugated
€409 - €559

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Description

system_update_altDatasheetsystem_update_altMSDS

Recombinant Phospho-CDK1, 2 (Thr14) Monoclonal Antibody

The Recombinant Phospho-CDK1, 2 (Thr14) Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110768) against CDK1, 2 (Thr14). The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by IHC analysis of Human colon. The target is localized to the Nucleus. Cytoplasm, mitochondrion, cytoplasm, cytoskeleton, microtubule organizing center, centrosome, cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.

Product Name:Recombinant Phospho-CDK1, 2 (Thr14) Monoclonal Antibody
SKU:AGEL6076
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:CDC, CDC2, CDC28A, CDK, CDK1, CDK1/CDC2, CDKN, CDKN1, cyclin dependent kinase 1874, cyclin-dependent kinase, cyclin-dependent kinase 1, P34CDC, P34CDC2
Reactivity:Human, Mouse, Rat
Immunogen:A synthetic peptide corresponding to residues around (Thr14) of Human Phospho-CDK1, 2
Applications:WBIHCIFIPELISA
Clonality:Recombinant Monoclonal
Clone No:C110768
Host:Rabbit
Isotype:Rabbit IgG
Target:CDK1, 2 (Thr14)
Conjugation:Unconjugated
Recommended Dilution:IHC 1:200-1000; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:P06493, P24941
Purification:Protein A
Concentration:0.2 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
Product ImageImmunohistochemistry of paraffin-embedded human colon using Recombinant Phospho-CDK1, 2 (Thr14) Monoclonal Antibody at dilution of 1:200.
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