The Recombinant Ret Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C111458) against Ret. The Ret is a receptor tyrosine kinase that functions as a multicomponent receptor complex in conjunction with other membrane-bound, ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotrophic factor (GDNF) and its congeners neurturin, persephin, and artemin. Research studies have shown that alterations in the corresponding RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung’s disease. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC-P, ICC/IF and IP applications. It has been validated by IF analysis of Neuro-2a. The target is localized to the endosome, membrane.
Product Name:
Recombinant Ret Monoclonal Antibody
SKU:
AGEL6763
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
Cadherin family member, Cadherin family member 12, CDHF, CDHF12, CDHR, CDHR16, HSCR, HSCR1, MEN2A, MEN2B, MTC, MTC1, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor Ret, PTC, RET, RET-ELE, RET-ELE1, RET51
Reactivity:
Human, Mouse, Rat
Immunogen:
A synthetic peptide of human Ret
Applications:
WBIHC-PICC/IFIP
Clonality:
Recombinant Monoclonal
Clone No:
C111458
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
Ret
Conjugation:
Unconjugated
Observed MW:
175, 150 kDa
Calculated MW:
124 kDa
Recommended Dilution:
WB 1:1000-5000; IHC-P 1:50; ICC/IF 1:50-100; IP 1:10-100
UniProt:
P07949, P35546, G3V9H8
Purification:
Protein A
Concentration:
1 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
