The Recombinant STAT5b Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C123299) against STAT5b. STAT5B belongs to the transcription factor STAT family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B carries out a dual function: signal transduction and activation of transcription. Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB and IHC-P applications. It has been validated by WB analysis of Hela, A549, HL-60 and IHC analysis of Human breast cancer. The target is localized to the Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.