The Recombinant STING Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C111289) against STING. STING has several transmembrane domains, and is expressed in a variety of endothelial cells, epithelial cells and hematopoietic liver cells. STING participates in the DNA-mediated innate immune response. Non-CpG double-stranded DNA from viruses or bacteria binds to cGAS protein and is catalyzed to the second messenger cGAMP; then the dimerized STING binds to cGAMP and undergoes conformational changes. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by WB analysis of Jurkat, K562, Rat spleen, HL60, HUVEC, Human CAF, HCT116, A549, HT22, Thp-1, HK-2, PC-12, 3T3-L1, PC-3, U-14, 293F, K562 WT and knockdown cell, IHC analysis of Rat colon, Rat spleen, Human tonsil and IF analysis of HEK293. The target is localized to the endoplasmic reticulum membrane, autophagosome membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane.
Product Name:
Recombinant STING Monoclonal Antibody
SKU:
AGEL6594
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
endoplasmic reticulum IFN stimulator, Endoplasmic reticulum interferon stimulator, ERIS, FLJ38577, hMITA, hSTING, Mediator of IRF3 activation, MITA, Mitochondrial mediator of IRF3 activation, MPYS, N terminal methionine proline tyrosine serine plasma membrane tetraspanner, NET, NET23, SAVI, Stimulator of interferon genes, Stimulator of interferon genes protein, STING, STING1, TM173, TMEM, TMEM173, Transmembrane protein 173
Reactivity:
Human, Mouse, Rat
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
Applications:
WBIHCIFIPELISA
Clonality:
Recombinant Monoclonal
Clone No:
C111289
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
STING
Conjugation:
Unconjugated
Observed MW:
37 kDa
Calculated MW:
42 kDa
Recommended Dilution:
WB 1:1000-5000; IHC 1:200-1000; IF 1:200-1000; IP 1:50-200; ELISA 1:5000-20000
UniProt:
Q86WV6, Q3TBT3
Purification:
Protein A
Concentration:
1 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
![Anti-STING [R06-9A7] Monoclonal Antibody (AGMB00567)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/271856/691075/anti-sting-r06-9a7-monoclonal-antibody-agmb00567__98016.1774501875.jpg?c=2 "Anti-STING [R06-9A7] Monoclonal Antibody (AGMB00567)")
