The Recombinant Thymidylate Synthase Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C311297) against Thymidylate Synthase. Thymidylate synthase (TS) is a key enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for DNA biosynthesis. Thymine nucleotide synthase is a key enzyme in the de novo synthesis pathway of mitochondrial thymine. For this reason, it is a key target for cancer chemotherapy, and considered to be the main target of 5-fluorouric acid, 5-fluoro-2'-deoxyribonucleic acid and some folate compounds. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB, IHC, IF and IP applications. It has been validated by WB analysis of HeLa, Jurkat, Raw264.7, 293T, Raji, IHC analysis of Human colon cancer, Human ovarian cancer, IF analysis of Jurkat and IP analysis of Jurkat cells extracts. The target is localized to the nucleus, cytoplasm, mitochondrion, mitochondrion matrix, mitochondrion inner membrane.