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Recombinant Thymidylate Synthase Monoclonal Antibody (AGEL6739)

Datasheet MSDS
SKU AGEL6739
Product Type Antibody
Reactivity Human, Rat, Mouse
Applications WB, IF, FCM
Host Species Rabbit
Clonality Monoclonal
Clone C171434
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant Thymidylate Synthase Monoclonal Antibody

The Recombinant Thymidylate Synthase Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C171434) against Thymidylate Synthase. Thymidylate synthase is a homodimer composed of two 30 kDa subunits, which catalyze the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), an essential step in the formation of thymine nucleotides. Thymidylate synthase is an intracellular enzyme that provides the sole de novo source of thymidylate, making it a required enzyme in DNA biosynthesis with activity highest in proliferating cells. Being the exclusive source of dTMP, investigators have concluded that TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head, and neck. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.

This antibody is suitable for WB, IF and FCM applications. It has been validated by WB analysis of HeLa, Jurkat, HepG2, RAW 264.7, C6, IF analysis of HeLa, Jurkat and FCM analysis of HeLa. The target is localized to the cytoplasm, nucleus.

Product Name:Recombinant Thymidylate Synthase Monoclonal Antibody
SKU:AGEL6739
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:HST, HST422, OK/SW-cl, OK/SW-cl.29, thymidylate synthase, thymidylate synthetase, TMS, TS, TYMS
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant human Thymidylate Synthase fragment
Applications:WBIFFCM
Clonality:Recombinant Monoclonal
Clone No:C171434
Host:Rabbit
Isotype:Rabbit IgG
Target:Thymidylate Synthase
Conjugation:Unconjugated
Observed MW:36 kDa
Calculated MW:36 kDa
Recommended Dilution:WB 1:500-2000; IF 1:50; FCM 1:50-100
UniProt:P04818
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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