The Recombinant TMPRSS2 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C721300) against TMPRSS2. Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human and Rat samples.
This antibody is suitable for WB, IHC and FCM applications. It has been validated by WB analysis of Rat kidney, IHC analysis of Human kidney and FCM analysis of LNCaP. The target is localized to the plasma membrane.
Product Name:
Recombinant TMPRSS2 Monoclonal Antibody
SKU:
AGEL6605
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
PP9284, PRSS, PRSS10, TMPRSS, TMPRSS2
Reactivity:
Human, Rat
Immunogen:
Recombinant human TMPRSS2 fragment
Applications:
WBIHCFCM
Clonality:
Recombinant Monoclonal
Clone No:
C721300
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
TMPRSS2
Conjugation:
Unconjugated
Observed MW:
52 kDa
Calculated MW:
54 kDa
Recommended Dilution:
WB 1:500-1000; IHC 1:50-100; FCM 1:50-100
UniProt:
O15393
Purification:
Protein A
Concentration:
1 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.