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Anti-SLC5A7 Antibody (CAB8247)

SKU:
CAB8247
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
$167 - $503
Frequently bought together:

Description

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Antibody Name:Anti-SLC5A7 Antibody
Antibody SKU:CAB8247
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 421-580 of human SLC5A7 (NP_068587.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:C6, SH-SY5Y, U-251MG, SGC-7901, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 421-580 of human SLC5A7 (NP_068587.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLCV LFVK GTNT YGAV AGYV SGLF LRIT GGEP YLYL QPLI FYPG YYPD DNGI YNQK FPFK TLAM VTSF LTNI CISY LAKY LFES GTLP PKLD VFDA VVAR HSEE NMDK TILV KNEN IKLD ELAL VKPR QSMT LSST FTNK EAFL DVDS SPEG SGTE DNLQ
Gene ID:60482
Uniprot:Q9GZV3
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:63kDa
Observed MW:66-75KDa
Synonyms:SLC5A7, CHT, CHT1, CMS20, HMN7A
Background:This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:SLC5A7: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: cell soma; integral to membrane; plasma membrane

Molecular Function:choline binding; choline transmembrane transporter activity; choline:sodium symporter activity

Biological Process: synaptic transmission; acetylcholine biosynthetic process; neurotransmitter secretion; sodium ion transport; neuromuscular synaptic transmission; choline transport; transmembrane transport; synaptic transmission, cholinergic

Disease: Neuronopathy, Distal Hereditary Motor, Type Viia

NCBI Summary:Choline is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., 2000 [PubMed 11027560]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9GZV3
NCBI GenInfo Identifier:56404957
NCBI Gene ID:10992
NCBI Accession:Q9GZV3.1
UniProt Secondary Accession:Q9GZV3,Q53TF2,
UniProt Related Accession:Q9GZV3
Molecular Weight:895
NCBI Full Name:High affinity choline transporter 1
NCBI Synonym Full Names:solute carrier family 5 (sodium/choline cotransporter), member 7
NCBI Official Symbol:SLC5A7  
NCBI Official Synonym Symbols:CHT; CHT1; hCHT; HMN7A  
NCBI Protein Information:high affinity choline transporter 1; solute carrier family 5 member 7; hemicholinium-3-sensitive choline transporter; solute carrier family 5 (choline transporter), member 7; high affinity choline transporter; hemicholinium-3-sensitive choline transporter
UniProt Protein Name:High affinity choline transporter 1
UniProt Synonym Protein Names:Hemicholinium-3-sensitive choline transporter; CHT; Solute carrier family 5 member 7
Protein Family:Splicing factor
UniProt Gene Name:SLC5A7  
UniProt Entry Name:SC5A7_HUMAN
Anti-SLC5A7 Antibody (CAB8247)`- SLC5A7 Rabbit pAb (CAB8247)

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