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Anti-SMARCD2 Antibody (CAB12104)

SKU:
CAB12104
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-SMARCD2 Antibody CAB12104
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-SMARCD2 Antibody CAB12104
€139 - €419
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Description

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Antibody Name:Anti-SMARCD2 Antibody
Antibody SKU:CAB12104
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 454-531 of human SMARCD2 (NP_001091896.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HT-29, HeLa, LO2, Jurkat, BxPC-3, Mouse thymus, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 454-531 of human SMARCD2 (NP_001091896.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RDFM LSFS TDPQ DFIQ EWLR SQRR DLKI ITDV IGNP EEER RAAF YHQP WAQE AVGR HIFA KVQQ RRQE LEQV LGIR LT
Gene ID:6603
Uniprot:Q92925
Cellular Location:Nucleus
Calculated MW:55kDa/57kDa/58kDa
Observed MW:64kDa
Synonyms:SMARCD2, BAF60B, CRACD2, PRO2451, Rsc6p, SGD2
Background:The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:SMARCD2: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the SMARCD family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: nuclear chromatin; nucleoplasm; protein complex; SWI/SNF complex

Molecular Function:nucleosomal DNA binding; protein binding

Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; nucleosome disassembly

NCBI Summary:The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q92925
NCBI GenInfo Identifier:322510105
NCBI Gene ID:6603
NCBI Accession:Q92925.3
UniProt Secondary Accession:Q92925,Q7L2I6, Q9UHZ1, A5PLL5, A6NNQ7, B4DV56, B4E1R6
UniProt Related Accession:Q92925
Molecular Weight:59kDa
NCBI Full Name:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
NCBI Synonym Full Names:SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
NCBI Official Symbol:SMARCD2  
NCBI Official Synonym Symbols:Rsc6p; BAF60B; CRACD2; PRO2451  
NCBI Protein Information:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
UniProt Protein Name:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
UniProt Synonym Protein Names:60 kDa BRG-1/Brm-associated factor subunit B; BRG1-associated factor 60B; BAF60B
Protein Family:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily
UniProt Gene Name:SMARCD2  
Anti-SMARCD2 Antibody (CAB12104)Western blot analysis of extracts of various cell lines, using SMARCD2 antibody (CAB12104) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-SMARCD2 Antibody (CAB12104)Immunohistochemistry of paraffin-embedded human esophageal cancer using SMARCD2 antibody (CAB12104) at dilution of 1:100 (40x lens).

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