SOD1 (UbetaB) Antibody is a rabbit polyclonal antibody directed against SOD1 (UbetaB), offered by Assay Genie for research applications. Reported applications include WB, ICC/IF and ELISA. Reported reactivity: Human, Mouse and Rat. Purified by Peptide Affinity.
Superoxide dismutase 1 (SOD1) is a copper- and zinc-binding antioxidant enzyme that catalyzes the dismutation of superoxide radicals (O₂⁻) into hydrogen peroxide (H₂O₂) and molecular oxygen (O₂), thereby mitigating oxidative stress in the cytoplasm. Structurally, SOD1 functions as a 32 kDa homodimer, with each 16 kDa subunit stabilized by an intra-subunit disulfide bond and a β-barrel fold critical for its enzymatic activity and structural integrity. In neurodegenerative disease research—particularly amyotrophic lateral sclerosis (ALS)—SOD1 has emerged as a central player. Mutations in the SOD1 gene can lead to protein misfolding, aggregation, and toxic gain-of-function effects. A key pathological hallmark involves the exposure of normally buried regions of the β-barrel, including the unfolded β-barrel domain, which is implicated in early misfolding events. Conformation-specific antibodies such as Anti-SOD1 (UbetaB), which selectively binds the unfolded β-barrel region, are powerful tools for detecting misfolded SOD1 in affected tissues. When used alongside antibodies like Anti-SOD1 (EDI), which targets the exposed dimer interface, researchers can map conformational states of SOD1 and track disease progression at the molecular level. Understanding and detecting these structural transitions in SOD1 is essential for advancing ALS diagnostics and developing targeted therapeutics in neurodegenerative disease research. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
SOD1 (UbetaB) Antibody
Product SKU:
STPA00041
Size:
100 µg
Target:
SOD1 (UbetaB)
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Cancer, Oxidative Stress, Neuroscience, Neurodegeneration, ALS Disease
Buffer:
PBS, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ICC/IF, ELISA
Purification:
Peptide Affinity purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Recognizes a conformation specific epitope where the beta barrel is unfolded.
Guarantee:
12 months from date of dispatch
Immunogen:
Within 50 AA of N-terminal region of human SOD1, unfolded beta barrel region
