SRI Antibody (PACO42945)
- SKU:
- PACO42945
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SRI Antibody (PACO42945) |
| Antibody SKU: | PACO42945 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sorcin protein (1-198AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: SRI antibody at 2µg/ml. Lane 1: HepG2 whole cell lysate. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 22, 21 kDa. Observed band size: 22 kDa. |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO42945 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO42945 at dilution of 1:100. |
| Background: | Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. |
| Synonyms: | Sorcin (22 kDa protein) (CP-22) (CP22) (V19), SRI |
| UniProt Protein Function: | SRI: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 7q21.1 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; membrane; mitochondrion; sarcoplasmic reticulum; T-tubule; cytoplasm; nerve terminal; cytosol; Z disc Molecular Function:protein binding; protease binding; protein heterodimerization activity; calcium channel regulator activity; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; receptor binding Biological Process: regulation of action potential; cytoplasmic sequestering of transcription factor; muscle development; negative regulation of heart rate; heart development; regulation of striated muscle contraction; regulation of calcium ion transport; proteolysis; signal transduction; regulation of heart contraction; transport; calcium ion transport; positive regulation of release of sequestered calcium ion into cytosol; intracellular sequestering of iron ion |
| NCBI Summary: | This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P30626 |
| NCBI GenInfo Identifier: | 267021 |
| NCBI Gene ID: | 6717 |
| NCBI Accession: | P30626.1 |
| UniProt Secondary Accession: | P30626,A8MTH6, B4DKK2, D6W5Q0, |
| UniProt Related Accession: | P30626 |
| Molecular Weight: | 198 |
| NCBI Full Name: | Sorcin |
| NCBI Synonym Full Names: | sorcin |
| NCBI Official Symbol: | SRI |
| NCBI Official Synonym Symbols: | SCN; V19; CP22; CP-22 |
| NCBI Protein Information: | sorcin; H_RG167B05.1; 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells |
| UniProt Protein Name: | Sorcin |
| UniProt Synonym Protein Names: | 22 kDa protein; CP-22; CP22; V19 |
| UniProt Gene Name: | SRI |
| UniProt Entry Name: | SORCN_HUMAN |
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