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Anti-STK38L Antibody (CAB15406)

SKU:
CAB15406
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 2 Anti-STK38L Antibody CAB15406
  • Signal Transduction Antibodies 2 Anti-STK38L Antibody CAB15406
€139 - €419
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Description

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Antibody Name:Anti-STK38L Antibody
Antibody SKU:CAB15406
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 165-464 of human STK38L (NP_055815.1).
Application:WB IF
Recommended Dilution:WB 1:200 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse small intestine, Mouse brain, Rat stomach, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 165-464 of human STK38L (NP_055815.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LIME FLPG GDMM TLLM KKDT LTEE ETQF YISE TVLA IDAI HQLG FIHR DIKP DNLL LDAK GHVK LSDF GLCT GLKK AHRT EFYR NLTH NPPS DFSF QNMN SKRK AETW KKNR RQLA YSTV GTPD YIAP EVFM QTGY NKLC DWWS LGVI MYEM LIGY PPFC SETP QETY RKVM NWKE TLVF PPEV PISE KAKD LILR FCID SENR IGNS GVEE IKGH PFFE GVDW EHIR ERPA AIPI EIKS IDDT SNFD DFPE SDIL QPVP NTTE PDYK SKDW VFLN YTYK RFEG LTQR GSIP TYMK AGKL
Gene ID:23012
Uniprot:Q9Y2H1
Cellular Location:Cytoplasm, Membrane, cytoskeleton
Calculated MW:43kDa/54kDa
Observed MW:54kDa
Synonyms:STK38L, NDR2
Background:
UniProt Protein Function:NDR2: a non-receptor S/T kinase of the AGC group. Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind followed by autophosphorylation of a serine in the kinase domain. A threonine in the C-terminal domain then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between the phosphorylated threonine and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. May be involved in the regulation of structural processes in neuronal cells.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; NDR family

Chromosomal Location of Human Ortholog: 12p11.23

Cellular Component: actin cytoskeleton; cytoplasm

Molecular Function:ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity

Biological Process: peptidyl-serine phosphorylation; protein amino acid phosphorylation; regulation of cellular component organization and biogenesis

UniProt Code:Q9Y2H1
NCBI GenInfo Identifier:56749668
NCBI Gene ID:23012
NCBI Accession:Q9Y2H1.3
UniProt Secondary Accession:Q9Y2H1,Q8TBX7, A8K4U0, B4E3J8,
UniProt Related Accession:Q9Y2H1
Molecular Weight:43,170 Da
NCBI Full Name:Serine/threonine-protein kinase 38-like
NCBI Synonym Full Names:serine/threonine kinase 38 like
NCBI Official Symbol:STK38L  
NCBI Official Synonym Symbols:NDR2  
NCBI Protein Information:serine/threonine-protein kinase 38-like
UniProt Protein Name:Serine/threonine-protein kinase 38-like
UniProt Synonym Protein Names:NDR2 protein kinase; Nuclear Dbf2-related kinase 2
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:STK38L  
UniProt Entry Name:ST38L_HUMAN
Anti-STK38L Antibody (CAB15406)Western blot analysis of extracts of various cell lines, using STK38L Rabbit pAb (CAB15406) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-STK38L Antibody (CAB15406)Immunofluorescence analysis of L929 cells using STK38L antibody (CAB15406) at dilution of 1:100. Blue: DAPI for nuclear staining.

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