SUR1 Antibody [N289/16 (Formerly sold as S289-16)]
SUR1 Antibody [N289/16 (Formerly sold as S289-16)] is a mouse monoclonal antibody directed against SUR1, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse, Rat and Hamster. Supplied as IgG1, purified by Protein G.
Sulfonylurea receptor 1 (SUR1), encoded by the ABCC8 gene, is a regulatory subunit of ATP-sensitive potassium (KATP) channels, which are critical for cellular energy sensing. SUR1 forms a functional complex with inward-rectifier potassium channel subunits Kir6.1 or Kir6.2, assembling into octameric KATP channels that couple cellular metabolic state to membrane excitability. These channels are best known for their role in pancreatic β-cells, where they regulate insulin secretion in response to intracellular ATP/ADP levels. Beyond the pancreas, SUR1 is increasingly recognized for its role in the central nervous system. In neurons and glial cells, SUR1-regulated KATP channels help maintain ionic homeostasis and protect against metabolic stress. Dysregulation of SUR1 expression or function has been implicated in a range of neuropathological conditions, including stroke, traumatic brain injury, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Notably, SUR1 upregulation is associated with the formation of pathological SUR1–TRPM4 channels, which contribute to cerebral edema and secondary injury. As a metabolic sensor and regulator of ion flux, SUR1 represents a promising therapeutic target in neuroscience. Pharmacological modulation of SUR1-containing channels—originally developed for diabetes—may offer neuroprotective benefits by stabilizing neuronal excitability, reducing inflammation, and mitigating energy failure in neurodegenerative contexts. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
SUR1 Antibody [N289/16 (Formerly sold as S289-16)]
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat, Hamster
Recommended Dilution:
WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~160kDa. Does not cross-react with SUR2B.
Guarantee:
12 months from date of dispatch
Immunogen:
Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
Immunogen Species:
Rat
Accession Number:
NP_037171.2
Gene ID:
1969-12-22 00:00:00
Swiss-Prot:
Q09429
Cellular Localization:
Membrane
Alternative Names:
AM60008PU-N, ABC36, Abcc8, ATP binding cassette sub family C member 8, HHF1, HRINS, MRP8, PHHI, SUR, SUR1, Sulfonylurea receptor (hyperinsulinemia), ATP binding cassette sub family C (CFTR/MRP) member 8, ATP binding cassette transporter sub family C member 8 (1), ATP-binding cassette sub-family C member 8, HI, SUR1delta2, TNDM2
