Anti-TAB1 Antibody (CAB3306)

Product Name:	TAB1 Rabbit mAb
Product Code:	CAB3306
Size:	20uL, 50uL, 100uL
Synonyms:	3'-Tab1, MAP3K7IP1
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human TAB1

Applications:	WB, IF
Recommended Dilutions:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, 293T, Mouse brain, Rat brain

Immunogen:	A synthesized peptide derived from human TAB1
Purification Method:	Affinity purification
Storage:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	10454
Uniprot:	Q15750
Calculated MW:	55kDa
Observed MW:	55kDa

UniProt Protein Function:	TAB1: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Activator; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: nucleoplasm; protein complex; cytoplasm; endosome membrane; cytosol Molecular Function:protein binding; mitogen-activated protein kinase p38 binding; enzyme activator activity; protein complex binding; kinase activator activity; catalytic activity Biological Process: heart morphogenesis; I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; in utero embryonic development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; transforming growth factor beta receptor signaling pathway; toll-like receptor signaling pathway; activation of MAPKKK activity; JNK cascade; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; lung development
NCBI Summary:	The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:	Q15750
NCBI GenInfo Identifier:	10720303
NCBI Gene ID:	10454
NCBI Accession:	Q15750.1
UniProt Secondary Accession:	Q15750,Q2PP09, Q8IZW2,
UniProt Related Accession:	Q15750
Molecular Weight:	504
NCBI Full Name:	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
NCBI Synonym Full Names:	TGF-beta activated kinase 1/MAP3K7 binding protein 1
NCBI Official Symbol:	TAB1
NCBI Official Synonym Symbols:	3'-Tab1; MAP3K7IP1
NCBI Protein Information:	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TAK1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1; mitogen-activated protein kinase kinase kinase 7-interacting protein 1
UniProt Protein Name:	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
UniProt Synonym Protein Names:	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1
Protein Family:	TGF-beta-activated kinase 1 and MAP3K7-binding protein
UniProt Gene Name:	TAB1
UniProt Entry Name:	TAB1_HUMAN