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Anti-TEAD1/2/3/4 Antibody (CAB5092)

SKU:
CAB5092
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TEAD1/2/3/4 Antibody
Antibody SKU:CAB5092
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TEAD1/2/3/4
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T, BxPC-3
Immunogen:A synthesized peptide derived from human TEAD1/2/3/4
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7003
Uniprot:P28347/Q15561/Q15562/Q99594
Cellular Location:
Calculated MW:54kDa
Observed MW:52KDa
Synonyms:AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1
Background:This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
UniProt Protein Function:TEAD1: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm

Molecular Function:protein binding; DNA binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; gene expression

Disease: Sveinsson Chorioretinal Atrophy

NCBI Summary:This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
UniProt Code:P28347
NCBI GenInfo Identifier:3041733
NCBI Gene ID:7003
NCBI Accession:P28347.2
UniProt Secondary Accession:P28347,A4FUP2, E7EV65,
UniProt Related Accession:P28347
Molecular Weight:426
NCBI Full Name:Transcriptional enhancer factor TEF-1
NCBI Synonym Full Names:TEA domain family member 1 (SV40 transcriptional enhancer factor)
NCBI Official Symbol:TEAD1  
NCBI Official Synonym Symbols:AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1  
NCBI Protein Information:transcriptional enhancer factor TEF-1; protein GT-IIC; transcription factor 13; transcriptional enhancer factor 1
UniProt Protein Name:Transcriptional enhancer factor TEF-1
UniProt Synonym Protein Names:NTEF-1; Protein GT-IIC; TEA domain family member 1; TEAD-1; Transcription factor 13; TCF-13
Protein Family:Transcriptional enhancer factor
UniProt Gene Name:TEAD1  
UniProt Entry Name:TEAD1_HUMAN
Anti-TEAD1/2/3/4 Antibody (CAB5092)Western blot - TEAD1/2/3/4 Rabbit mAb (CAB5092)

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