TNPO2 Antibody (PACO12839)
- SKU:
- PACO12839
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | TNPO2 Antibody (PACO12839) |
Antibody SKU: | PACO12839 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human TNPO2 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | transportin 2;TNPO2;FLJ12155;IPO3;KPNB2B;TRN2 ; |
UniProt Protein Function: | TNPO2: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nuclear import; Karyopherin Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; nuclear localization sequence binding; Ran GTPase binding Biological Process: intracellular protein transport |
UniProt Code: | O14787 |
NCBI GenInfo Identifier: | 209969836 |
NCBI Gene ID: | 30000 |
NCBI Accession: | NP_001129667.1 |
UniProt Secondary Accession: | O14787,O14655, Q6IN77, |
UniProt Related Accession: | O14787 |
Molecular Weight: | 100,408 Da |
NCBI Full Name: | transportin-2 isoform 2 |
NCBI Synonym Full Names: | transportin 2 |
NCBI Official Symbol: | TNPO2Â Â |
NCBI Official Synonym Symbols: | IPO3; TRN2; KPNB2BÂ Â |
NCBI Protein Information: | transportin-2; importin 3; karyopherin beta 2b, transportin; karyopherin beta-2b; transportin 2 (importin 3, karyopherin beta 2b) |
UniProt Protein Name: | Transportin-2 |
UniProt Synonym Protein Names: | Karyopherin beta-2b |
Protein Family: | Transportin |
UniProt Gene Name: | TNPO2Â Â |
UniProt Entry Name: | TNPO2_HUMAN |