Description
TNPO2 Antibody (PACO12839)
The TNPO2 Polyclonal Antibody (PAC012839) is a valuable tool for researchers studying TNPO2, a key protein involved in nuclear transport. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting TNPO2 in human samples. Validated for use in Western blot applications, it enables precise analysis of TNPO2 expression in various cell types.TNPO2, also known as transportin-2, plays a crucial role in the transport of proteins into the cell nucleus, influencing gene expression and cell function. Dysregulation of TNPO2 has been implicated in various diseases, including cancer and viral infections.
Therefore, studying TNPO2 expression and function is essential for gaining insights into disease mechanisms and developing targeted therapies.With its ability to specifically recognize TNPO2, the PAC012839 antibody is an invaluable tool for researchers investigating nuclear transport processes and their implications in health and disease. Its reliability and accuracy make it a valuable asset in the fields of molecular biology, cell biology, and drug discovery.
| Antibody Name: | TNPO2 Antibody (PACO12839) |
| Antibody SKU: | PACO12839 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human TNPO2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | transportin 2;TNPO2;FLJ12155;IPO3;KPNB2B;TRN2 ; |
| UniProt Protein Function: | TNPO2: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear import; Karyopherin Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; nuclear localization sequence binding; Ran GTPase binding Biological Process: intracellular protein transport |
| UniProt Code: | O14787 |
| NCBI GenInfo Identifier: | 209969836 |
| NCBI Gene ID: | 30000 |
| NCBI Accession: | NP_001129667.1 |
| UniProt Secondary Accession: | O14787,O14655, Q6IN77, |
| UniProt Related Accession: | O14787 |
| Molecular Weight: | 100,408 Da |
| NCBI Full Name: | transportin-2 isoform 2 |
| NCBI Synonym Full Names: | transportin 2 |
| NCBI Official Symbol: | TNPO2Â Â |
| NCBI Official Synonym Symbols: | IPO3; TRN2; KPNB2BÂ Â |
| NCBI Protein Information: | transportin-2; importin 3; karyopherin beta 2b, transportin; karyopherin beta-2b; transportin 2 (importin 3, karyopherin beta 2b) |
| UniProt Protein Name: | Transportin-2 |
| UniProt Synonym Protein Names: | Karyopherin beta-2b |
| Protein Family: | Transportin |
| UniProt Gene Name: | TNPO2Â Â |
| UniProt Entry Name: | TNPO2_HUMAN |
