null

Anti-TUBGCP6 Antibody (CAB15921)

SKU:
CAB15921
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 6 Anti-TUBGCP6 Antibody CAB15921
  • Cell Biology Antibodies 6 Anti-TUBGCP6 Antibody CAB15921
  • Cell Biology Antibodies 6 Anti-TUBGCP6 Antibody CAB15921
  • Cell Biology Antibodies 6 Anti-TUBGCP6 Antibody CAB15921
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TUBGCP6 Antibody
Antibody SKU:CAB15921
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human TUBGCP6 (NP_065194.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human TUBGCP6 (NP_065194.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KTIN LLKL CCPR HYLC WSDV PVPR ISVI FSLE ELKE IEKD CAVY VGRM ERVA RHSS VSKE EKEL RMEI AKQE LIAH AREA ASRV LSAL SDRQ MSER MALD ARKR EQFQ RLKE QFVK DQER RQAA RQEE LDDD FSYA RELR DRER RLKS LEEE LERK ARQA LVDH YSKL SAEA ARRE QKAL WRIQ RHRL ESAR LRFL LEDE KHIQ EMLK AVSE AHQP QEPP DVLL SVHP QVTS PGPE HPEG GQGC DSGS AEQH SPAW DGWN RPGL LTPQ PLKP LAVG AGGR GLQQ AEGA RPFS DSLS IGDF L
Gene ID:85378
Uniprot:Q96RT7
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:196kDa/198kDa/200kDa
Observed MW:250kDa
Synonyms:TUBGCP6, GCP-6, GCP6, MCCRP, MCCRP1, MCPHCR
Background:The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome.
UniProt Protein Function:GCP6: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Defects in TUBGCP6 are the cause of microcephaly with chorioretinopathy, autosomal recessive (MCPHCR). A syndrome characterized by microcephaly, cognitive impairment, underdeveloped retina and choroid, and epilepsy in some patients. The more anterior parts of the retina, near the periphery and pars plana, have a grayish hue and diminutive vasculature similar to retinopathy of prematurity. Visual impairment becomes evident during the first year of life. Belongs to the TUBGCP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q13.31-q13.33

Cellular Component: centrosome; cytosol; gamma-tubulin ring complex; membrane; microtubule; spindle pole body

Molecular Function:gamma-tubulin binding; microtubule binding; microtubule minus-end binding; structural constituent of cytoskeleton

Biological Process: centrosome duplication; cytoplasmic microtubule organization and biogenesis; G2/M transition of mitotic cell cycle; interphase microtubule nucleation by interphase microtubule organizing center; meiosis; microtubule nucleation; mitotic cell cycle

Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive 1

NCBI Summary:The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008]
UniProt Code:Q96RT7
NCBI GenInfo Identifier:143811395
NCBI Gene ID:85378
NCBI Accession:Q96RT7.3
UniProt Secondary Accession:Q96RT7,Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4
UniProt Related Accession:Q96RT7
Molecular Weight:198,761 Da
NCBI Full Name:Gamma-tubulin complex component 6
NCBI Synonym Full Names:tubulin gamma complex associated protein 6
NCBI Official Symbol:TUBGCP6  
NCBI Official Synonym Symbols:GCP6; GCP-6; MCCRP; MCCRP1; MCPHCR  
NCBI Protein Information:gamma-tubulin complex component 6
UniProt Protein Name:Gamma-tubulin complex component 6
Protein Family:Gamma-tubulin complex component
UniProt Gene Name:TUBGCP6  
UniProt Entry Name:GCP6_HUMAN
Anti-TUBGCP6 Antibody (CAB15921)Western blot analysis of extracts of various cell lines, using TUBGCP6 antibody (CAB15921) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-TUBGCP6 Antibody (CAB15921)Immunohistochemistry of paraffin-embedded Human colon carcinoma using TUBGCP6 Rabbit pAb (CAB15921) at dilution of 1:100 (40x lens).
Anti-TUBGCP6 Antibody (CAB15921)Immunohistochemistry of paraffin-embedded Rat testis using TUBGCP6 Rabbit pAb (CAB15921) at dilution of 1:100 (40x lens).
Anti-TUBGCP6 Antibody (CAB15921)Immunohistochemistry of paraffin-embedded Rat testis using TUBGCP6 Rabbit pAb (CAB15921) at dilution of 1:100 (20x lens).

Related Products