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Anti-UBD Antibody (CAB5491)

SKU:
CAB5491
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 3 Anti-UBD Antibody CAB5491
  • Signal Transduction Antibodies 3 Anti-UBD Antibody CAB5491
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-UBD Antibody
Antibody SKU:CAB5491
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human UBD (NP_006389.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human UBD (NP_006389.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAPN ASCL CVHV RSEE WDLM TFDA NPYD SVKK IKEH VRSK TKVP VQDQ VLLL GSKI LKPR RSLS SYGI DKEK TIHL TLKV VKPS DEEL PLFL VESG DEAK RHLL QVRR SSSV AQVK AMIE TKTG IIPE TQIV TCNG KRLE DGKM MADY GIRK GNLL FLAC YCIG G
Gene ID:10537
Uniprot:O15205
Cellular Location:Cytoplasm, Nucleus
Calculated MW:18kDa
Observed MW:24kDa
Synonyms:UBD, FAT10, GABBR1, UBD-3
Background:
UniProt Protein Function:FAT10: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN).
UniProt Protein Details:

Protein type:Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function:protein binding

Biological Process: myeloid dendritic cell differentiation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein modification by small protein conjugation; protein ubiquitination; proteolysis; response to organic nitrogen; ubiquitin-dependent protein catabolic process

UniProt Code:O15205
NCBI GenInfo Identifier:269849476
NCBI Gene ID:10537
NCBI Accession:O15205.2
UniProt Secondary Accession:O15205,Q5STL2, Q5SUK2, Q96EC7, B0UZT6,
UniProt Related Accession:O15205
Molecular Weight:
NCBI Full Name:Ubiquitin D
NCBI Synonym Full Names:ubiquitin D
NCBI Official Symbol:UBD  
NCBI Official Synonym Symbols:FAT10; UBD-3; GABBR1  
NCBI Protein Information:ubiquitin D
UniProt Protein Name:Ubiquitin D
UniProt Synonym Protein Names:Diubiquitin; Ubiquitin-like protein FAT10
Protein Family:Ubiquitin
UniProt Gene Name:UBD  
UniProt Entry Name:UBD_HUMAN
Anti-UBD Antibody (CAB5491)Western blot analysis of extracts of mouse liver, using UBD antibody (CAB5491) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-UBD Antibody (CAB5491)Immunofluorescence analysis of A-549 cells using UBD antibody (CAB5491). Blue: DAPI for nuclear staining.

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