Ubiquitin D Rabbit Monoclonal Antibody (CAB9005)

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SKU:
CAB9005
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Description

Technical Manual

Ubiquitin D Rabbit Monoclonal Antibody

Product Name:Ubiquitin D Rabbit Monoclonal Antibody
Product SKU:CAB9005
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:
Immunogen:A synthesized peptide derived from human Ubiquitin D
Sequence:

Email for sequence

Gene ID:10537
Swiss Prot:O15205
Synonyms:FAT10; GABBR1; UBD-3
Calculated MW:23kDa
Observed MW:22KDa
Reactivity:Human, Mouse, Rat
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunofluorescence 
Positive Samples:HeLa, NIH/3T3, Raji, HepG2
Cellular Location:

Product Images

Ubiquitin D Rabbit Monoclonal Antibody (CAB9005)

Western blot - Ubiquitin D Rabbit mAb (CAB9005)

Uniprot Information

UniProt Protein Function:FAT10: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)- associated nephropathy (HIVAN).
UniProt Protein Details:

Protein type:Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function:protein binding

Biological Process: myeloid dendritic cell differentiation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein modification by small protein conjugation; protein ubiquitination; proteolysis; response to organic nitrogen; ubiquitin-dependent protein catabolic process

UniProt Code:O15205
NCBI GenInfo Identifier:269849476
NCBI Gene ID:10537
NCBI Accession:O15205.2
UniProt Secondary Accession:O15205,Q5STL2, Q5SUK2, Q96EC7, B0UZT6,
UniProt Related Accession:O15205
Molecular Weight:
NCBI Full Name:Ubiquitin D
NCBI Synonym Full Names:ubiquitin D
NCBI Official Symbol:UBD 
NCBI Official Synonym Symbols:FAT10; UBD-3; GABBR1 
NCBI Protein Information:ubiquitin D
UniProt Protein Name:Ubiquitin D
UniProt Synonym Protein Names:Diubiquitin; Ubiquitin-like protein FAT10
Protein Family:Ubiquitin
UniProt Gene Name:UBD 
UniProt Entry Name:UBD_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
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