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Anti-ABL2 Antibody (CAB19628)

SKU:
CAB19628
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ABLL
ARG
€139 - €419
Frequently bought together:

Description

Product Name:ABL2 Rabbit mAb
Product Code:CAB19628
Size:20uL, 50uL, 100uL
Synonyms:ABLL, ARG
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ABL2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, U-87MG, Rat testis
Immunogen:A synthesized peptide derived from human ABL2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:27
Uniprot:P42684
Calculated MW:128kDa
Observed MW:128KDa
UniProt Protein Function:Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Oncoprotein; TK group; Abl family

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: actin cytoskeleton; cytosol; extrinsic to internal side of plasma membrane

Molecular Function:actin filament binding; actin monomer binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor binding

Biological Process: elevation of cytosolic calcium ion concentration; innate immune response; peptidyl-tyrosine phosphorylation; positive regulation of oxidoreductase activity; protein modification process; regulation of autophagy; regulation of cell adhesion; regulation of cell proliferation; regulation of endocytosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway

NCBI Summary:This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
UniProt Code:P42684
NCBI GenInfo Identifier:1168268
NCBI Gene ID:27
NCBI Accession:P42684.1
UniProt Secondary Accession:P42684,Q5T0X6, Q5W0C5, Q6NZY6, Q7Z301, A0M8X0, B7UEF2 B7UEF3, B7UEF4, B7UEF5,
UniProt Related Accession:P42684
Molecular Weight:60,864 Da
NCBI Full Name:Abelson tyrosine-protein kinase 2
NCBI Synonym Full Names:ABL proto-oncogene 2, non-receptor tyrosine kinase
NCBI Official Symbol:ABL2  
NCBI Official Synonym Symbols:ARG; ABLL  
NCBI Protein Information:Abelson tyrosine-protein kinase 2
UniProt Protein Name:Abelson tyrosine-protein kinase 2
UniProt Synonym Protein Names:Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
Protein Family:Abelson tyrosine-protein kinase
UniProt Gene Name:ABL2  
UniProt Entry Name:ABL2_HUMAN

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