ACHE Rabbit Polyclonal Antibody (CAB2806)
- SKU:
- CAB2806
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Neuroscience
Description
Product Name: | ACHE Rabbit Polyclonal Antibody |
SKU: | CAB2806 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 398-617 of human ACHE (NP_056646.1). |
Sequence: | VPQV SDLA AEAV VLHY TDWL HPED PARL REAL SDVV GDHN VVCP VAQL AGRL AAQG ARVY AYVF EHRA STLS WPLW MGVP HGYE IEFI FGIP LDPS RNYT AEEK IFAQ RLMR YWAN FART GDPN EPRD PKAP QWPP YTAG AQQY VSLD LRPL EVRR GLRA QACA FWNR FLPK LLSA TASE APST CPGF THGE AAPR PGLP LPLL LLHQ LLLL FLSH LRRL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | YT; ACEE; ARACHE; N-ACHE; ACHE |
Positive Sample: | SH-SY5Y,SGC996,Mouse brain,Mouse spinal cord,Mouse liver,Rat spinal cord |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Nucleus, Peripheral membrane protein, Secreted, synapse. |
Calculated MW: | 68kDa |
Observed MW: | 75kDa |
Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion
Purification Method: | Affinity purification |
Gene ID: | 43 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |