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Anti-ADCYAP1R1 Antibody (CAB3120)

SKU:
CAB3120
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
€139 - €419
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Description

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Antibody Name:Anti-ADCYAP1R1 Antibody
Antibody SKU:CAB3120
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human ADCYAP1R1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, SH-SY5Y, U-87MG
Immunogen:A synthetic peptide of human ADCYAP1R1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:117
Uniprot:P41586
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:46kDa/51kDa/53kDa/54kDa/56kDa
Observed MW:60kDa
Synonyms:ADCYAP1R1, PAC1, PAC1R, PACAPR, PACAPRI
Background:This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
UniProt Protein Function:ADCYAP1R1: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. Belongs to the G-protein coupled receptor 2 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p14

Cellular Component: neuron projection; cell surface; tight junction; rough endoplasmic reticulum; integral to plasma membrane; plasma membrane; caveola; receptor complex; endosome

Molecular Function:ADP-ribosylation factor binding; neuropeptide binding; vasoactive intestinal polypeptide receptor activity; protein binding; receptor activity; adenylate cyclase binding

Biological Process: response to drug; G-protein coupled receptor protein signaling pathway; development of primary female sexual characteristics; cAMP-mediated signaling; response to ethanol; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; phospholipase C activation; adenylate cyclase activation; spermatogenesis; cell differentiation; multicellular organismal response to stress; response to estradiol stimulus; transmembrane receptor protein tyrosine kinase signaling pathway

NCBI Summary:This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
UniProt Code:P41586
NCBI GenInfo Identifier:1171986
NCBI Gene ID:117
NCBI Accession:P41586.1
UniProt Related Accession:P41586
Molecular Weight:
NCBI Full Name:Pituitary adenylate cyclase-activating polypeptide type I receptor
NCBI Synonym Full Names:ADCYAP receptor type I
NCBI Official Symbol:ADCYAP1R1  
NCBI Official Synonym Symbols:PAC1; PAC1R; PACAPR; PACAPRI  
NCBI Protein Information:pituitary adenylate cyclase-activating polypeptide type I receptor
UniProt Protein Name:Pituitary adenylate cyclase-activating polypeptide type I receptor
Protein Family:PACRG-like protein
UniProt Gene Name:ADCYAP1R1  
UniProt Entry Name:PACR_HUMAN
Anti-ADCYAP1R1 Antibody (CAB3120)Western blot analysis of extracts of various cell lines, using ADCYAP1R1 antibody (CAB3120) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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