The alpha + beta Synuclein Monoclonal Antibody (CAB4899) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using rabbit monoclonal technology, offers high specificity and sensitivity for detecting alpha-beta synuclein in human samples.Validated for use in Western blot applications, this antibody binds specifically to alpha-beta synuclein, allowing for precise detection and analysis in various cell types. Its reliability and accuracy make it an essential tool for studies in neuroscience and neurodegenerative diseases.Alpha-beta synuclein plays a crucial role in the pathogenesis of Parkinson's disease and other related conditions, making it a valuable target for research aimed at understanding the underlying mechanisms of these disorders.
This antibody is validated for use in WB, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
alpha + beta Synuclein Monoclonal Antibody
SKU:
CAB4899
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1181
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Purification Method
Affinity purification
Gene ID
6622 6620
RRID
AB_2863382
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using alpha + beta Synuclein Rabbit mAb (CAB4899) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1min.
Western blot analysis of lysates from U-87MG cells, using alpha + beta Synuclein Rabbit mAb (CAB4899) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 3min.
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