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Anti-PP2A alpha + beta Antibody (CAB6175)

SKU:
CAB6175
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PP2Abeta
PP2CB
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:PP2A alpha + beta Rabbit mAb
Product Code:CAB6175
Size:20uL, 50uL, 100uL
Synonyms:PP2Abeta, PP2CB
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PP2A alpha + beta
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, NIH/3T3, Jurkat, C6, Mouse testis, Mouse brain, Rat lung, Rat testis
Immunogen:A synthesized peptide derived from human PP2A alpha + beta
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5516/5515
Uniprot:P62714/P67775
Calculated MW:36kDa
Observed MW:36kDa
UniProt Protein Function:PPP2CB: one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits.
UniProt Protein Details:

Protein type:Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: spindle pole; protein phosphatase type 2A complex; nucleus; cytosol; chromosome, pericentric region

Molecular Function:protein C-terminus binding; protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: response to antibiotic; proteasomal ubiquitin-dependent protein catabolic process; apoptotic mitochondrial changes; fibroblast growth factor receptor signaling pathway; response to hydrogen peroxide; regulation of gene expression; negative regulation of Ras protein signal transduction; protein amino acid dephosphorylation

NCBI Summary:This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
UniProt Code:P62714
NCBI GenInfo Identifier:50402236
NCBI Gene ID:5516
NCBI Accession:P62714.1
UniProt Secondary Accession:P62714,P67775, P62715, P63330, P62716 P63331,
UniProt Related Accession:P62714
Molecular Weight:35kDa
NCBI Full Name:Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
NCBI Synonym Full Names:protein phosphatase 2 catalytic subunit beta
NCBI Official Symbol:PPP2CB  
NCBI Official Synonym Symbols:PP2CB; PP2Abeta  
NCBI Protein Information:serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
UniProt Protein Name:Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Protein Family:PP2A regulatory
UniProt Gene Name:PPP2CB  
UniProt Entry Name:PP2AB_HUMAN

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