Anti-Phospho-PP2A alpha-Y307 Antibody (CABP1043)

SKU:
CABP1043
€129 - €389

Description

Technical Manual

Anti-Phospho-PP2A alpha-Y307 Antibody

Product Name:Anti-Phospho-PP2A alpha-Y307 Antibody
Product SKU:CABP1043
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

Immunogen:A phospho specific peptide corresponding to residues surrounding Y307 of human PP2A alpha
Sequence:

Email for sequence

Gene ID:5515
Swiss Prot:P67775
Synonyms:PP2Ac; PP2CA; PP2Calpha; RP-C
Calculated MW:35kDa
Observed MW:35KDa
Reactivity:Human, Mouse
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:NIH/3T3
Cellular Location:

Product Images

Anti-Phospho-PP2A alpha-Y307 Antibody (CABP1043)

Western blot - Phospho-PP2A alpha-Y307 Rabbit mAb (CABP1043)

Uniprot Information

UniProt Protein Function:PPP2CA: ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
UniProt Protein Details:

Protein type:EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; membrane; mitochondrion; plasma membrane; nucleus; cytosol; chromosome, pericentric region

Molecular Function:protein dimerization activity; protein C-terminus binding; protein binding; metal ion binding; GABA receptor binding; protein serine/threonine phosphatase activity

Biological Process: mitotic nuclear envelope reassembly; apoptosis; regulation of protein amino acid autophosphorylation; protein amino acid dephosphorylation; response to organic substance; regulation of transcription, DNA-dependent; meiotic cell cycle; regulation of cell differentiation; regulation of growth; mesoderm development; regulation of receptor activity; regulation of DNA replication; inactivation of MAPK activity; second-messenger-mediated signaling; regulation of cell adhesion; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat3 protein; mRNA catabolic process, nonsense-mediated decay; gene expression; regulation of protein catabolic process; mitotic cell cycle; negative regulation of cell growth; ceramide metabolic process

NCBI Summary:This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
UniProt Code:P67775
NCBI GenInfo Identifier:54038809
NCBI Gene ID:5515
NCBI Accession:P67775.1
UniProt Related Accession:P67775
Molecular Weight:
NCBI Full Name:Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
NCBI Synonym Full Names:protein phosphatase 2 catalytic subunit alpha
NCBI Official Symbol:PPP2CA 
NCBI Official Synonym Symbols:RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha 
NCBI Protein Information:serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
UniProt Protein Name:Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
UniProt Synonym Protein Names:Replication protein C
Protein Family:PP2A regulatory
UniProt Gene Name:PPP2CA 
UniProt Entry Name:PP2AA_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
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