Angpt2 Antibody (PACO33756)
- SKU:
- PACO33756
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Angpt2 Antibody (PACO33756) |
| Antibody SKU: | PACO33756 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Angiopoietin-2 protein (19-483AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Angpt2 antibody at 2µg/ml + Mouse lung tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 57 kDa Observed band size: 57 kDa . |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO33756 at dilution of 1:20. |
 | Immunohistochemistry of paraffin-embedded mouse kidney tissue using PACO33756 at dilution of 1:50. |
| Background: | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal |
| Synonyms: | Angiopoietin-2 (ANG-2), Angpt2, Agpt2 |
| UniProt Protein Function: | ANGPT2: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Cellular Component: extracellular space; cell projection; plasma membrane; extracellular region; nucleus Molecular Function:protein binding; metal ion binding; receptor tyrosine kinase binding; vascular endothelial growth factor receptor binding Biological Process: Tie receptor signaling pathway; multicellular organismal development; negative regulation of blood vessel endothelial cell migration; regulation of angiogenesis; negative regulation of positive chemotaxis; negative regulation of angiogenesis; positive regulation of angiogenesis; blood vessel morphogenesis; hemopoiesis; blood vessel remodeling; angiogenesis; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; endoderm development |
| NCBI Summary: | This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs. [provided by RefSeq, Jan 2013] |
| UniProt Code: | O35608 |
| NCBI GenInfo Identifier: | 31982508 |
| NCBI Gene ID: | 11601 |
| NCBI Accession: | NP_031452.2 |
| UniProt Secondary Accession: | O35608,Q3U1A1, Q9D2D2, |
| UniProt Related Accession: | O35608 |
| Molecular Weight: | 56,576 Da |
| NCBI Full Name: | angiopoietin-2 |
| NCBI Synonym Full Names: | angiopoietin 2 |
| NCBI Official Symbol: | Angpt2Â Â |
| NCBI Official Synonym Symbols: | Ang2; Agpt2; Ang-2Â Â |
| NCBI Protein Information: | angiopoietin-2 |
| UniProt Protein Name: | Angiopoietin-2 |
| UniProt Gene Name: | Angpt2Â Â |
| UniProt Entry Name: | ANGP2_MOUSE |
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