| UniProt Protein Function: | FBXO18: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. Belongs to the helicase family. UvrD subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Helicase; EC 3.6.4.12 Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: chromatin; nucleus; SCF ubiquitin ligase complex Molecular Function: 3'-5' DNA helicase activity; DNA helicase activity; DNA translocase activity; double-stranded DNA binding; protein binding; single-stranded DNA binding Biological Process: cell death; DNA catabolic process, endonucleolytic; double-strand break repair via homologous recombination; positive regulation of protein amino acid phosphorylation; protein ubiquitination; replication fork processing; replication fork protection; response to DNA damage stimulus |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NFZ0 |
| NCBI GenInfo Identifier: | 45476952 |
| NCBI Gene ID: | 84893 |
| NCBI Accession: | Q8NFZ0.2 |
| UniProt Secondary Accession: | Q8NFZ0,Q5JVB0, Q5JVB1, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586 Q96E82, Q96K67, Q96SW7 |
| UniProt Related Accession: | Q8NFZ0 |
| Molecular Weight: | 123,375 Da |
| NCBI Full Name: | F-box DNA helicase 1 |
| NCBI Synonym Full Names: | F-box protein, helicase, 18 |
| NCBI Official Symbol: | FBXO18 |
| NCBI Official Synonym Symbols: | FBH1; Fbx18; hFBH1 |
| NCBI Protein Information: | F-box DNA helicase 1 |
| UniProt Protein Name: | F-box DNA helicase 1 |
| UniProt Synonym Protein Names: | F-box only protein 18 |
| Protein Family: | F-box DNA helicase |
| UniProt Gene Name: | FBXO18 |
| UniProt Entry Name: | FBH1_HUMAN |
