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Anti-SUPT5H/SPT5 Antibody (CAB19225)

SKU:
CAB19225
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SUPT5H
SPT5
SPT5H
Tat-CT1
transcription elongation factor SPT5
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

Product Name:SUPT5H/SPT5 Rabbit mAb
Product Code:CAB19225
Size:20uL, 50uL, 100uL
Synonyms:SUPT5H, SPT5, SPT5H, Tat-CT1, transcription elongation factor SPT5
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SUPT5H/SPT5.
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa
Immunogen:Recombinant protein of human SUPT5H/SPT5.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6829
Uniprot:O00267
Cellular Location:Nucleus
Calculated MW:155kDa
Observed MW:150kDa
UniProt Protein Function:SPT5: a transcription elongation factor. Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Two alternatively spliced human isoforms have been described.
UniProt Protein Details:

Protein type:RNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: nucleoplasm; nucleus

Molecular Function:enzyme binding; protein binding; protein heterodimerization activity

Biological Process: mRNA capping; negative regulation of RNA elongation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of macroautophagy; positive regulation of RNA elongation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; response to organic substance; RNA elongation; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter

UniProt Code:O00267
NCBI GenInfo Identifier:74735318
NCBI Gene ID:6829
NCBI Accession:O00267.1
UniProt Secondary Accession:O00267,O43279, Q59G52, Q99639,
UniProt Related Accession:O00267
Molecular Weight:120,499 Da
NCBI Full Name:Transcription elongation factor SPT5
NCBI Synonym Full Names:SPT5 homolog, DSIF elongation factor subunit
NCBI Official Symbol:SUPT5H  
NCBI Official Synonym Symbols:SPT5; SPT5H; Tat-CT1  
NCBI Protein Information:transcription elongation factor SPT5
UniProt Protein Name:Transcription elongation factor SPT5
UniProt Synonym Protein Names:DRB sensitivity-inducing factor 160 kDa subunit; DSIF p160; DRB sensitivity-inducing factor large subunit; DSIF large subunit; Tat-cotransactivator 1 protein; Tat-CT1 protein
UniProt Gene Name:SUPT5H  
UniProt Entry Name:SPT5H_HUMAN

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