The Bcl10 Monoclonal Antibody (CAB4520) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced using cutting-edge technology in rabbit monoclonal antibody production, exhibits high specificity and sensitivity for detecting BCL10 in human samples. Validated for use in Western blot applications, this antibody binds specifically to the BCL10 protein, allowing for accurate detection and analysis in a variety of cell types.BCL10 is a key player in cell signaling pathways that control cell growth, differentiation, and apoptosis.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
Bcl10 Monoclonal Antibody
SKU:
CAB4520
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC2673
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CLAP, mE10, CIPER, IMD37, c-E10, CARMEN, Bcl10
Positive Sample:
K-562, Raji
Cellular Localization:
Cytoplasm, Membrane Raft, Perinuclear Region.
Calculated MW:
26kDa
Observed MW:
30kDa
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
8915
RRID
AB_2863286
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using Bcl10 Rabbit mAb (CAB4520) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
