The Biotinylated Anti-DNAM1 Antibody (HDLA057) is a valuable tool for research involving DNAM1, a cell surface receptor implicated in immune responses and cytotoxicity. This antibody, produced using a biotin-streptavidin detection system, shows high reactivity with human samples and is validated for use in various applications such as immunohistochemistry and flow cytometry.DNAM1, also known as CD226, plays a crucial role in immune surveillance and activation of natural killer (NK) cells. Its interactions with ligands such as CD155 and CD112 are important for NK cell-mediated cytotoxicity and immune responses against infected or cancerous cells.
Studying the expression and function of DNAM1 can provide valuable insights into immune regulation and potential therapeutic targets for diseases such as cancer and viral infections.This Biotinylated Anti-DNAM1 Antibody is an essential tool for researchers studying immune regulation, NK cell biology, and cancer immunotherapy. Its specificity and sensitivity make it a reliable reagent for detecting and analyzing DNAM1 expression in various cell types, advancing our understanding of immune responses and potential therapeutic interventions.
SKU:
HDLA057
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM95
Synonyms:
DNAM1, CD226, PTA1
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants.
