The Biotinylated Anti-ACE2 Antibody (HDLA012) is a valuable tool for researching ACE2, a key receptor protein involved in viral entry and immune response modulation. This polyclonal antibody, raised in rabbits, has high reactivity with human ACE2 samples and is validated for use in various applications including Western blot and immunofluorescence.ACE2, known for its role in the renin-angiotensin system, has garnered significant attention for its involvement in viral infections, particularly in the context of the COVID-19 pandemic. By targeting ACE2, researchers can gain insights into viral entry mechanisms, immune response modulation, and potential therapeutic interventions for viral diseases.
Studying ACE2 can also provide valuable information for understanding its involvement in other physiological processes such as cardiovascular function, kidney health, and respiratory disorders. This antibody enables precise detection and analysis of ACE2 protein levels in various cell types, making it an essential tool for research in virology, immunology, and respiratory health.
Product Code:
HDLA012
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM47
Synonyms:
ACE-2, ACEH, ACE2
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
