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[KO Validated] HP1 alpha/CBX5 Rabbit Polyclonal Antibody (CAB12577)

SKU:
CAB12577
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • KO Validated Antibodies 1 Anti-CBX5 Antibody CAB12577KO Validated
  • KO Validated Antibodies 1 Anti-CBX5 Antibody CAB12577KO Validated
  • KO Validated Antibodies 1 Anti-CBX5 Antibody CAB12577KO Validated
  • KO Validated Antibodies 1 Anti-CBX5 Antibody CAB12577KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] HP1 alpha/CBX5 Rabbit Polyclonal Antibody
SKU:CAB12577
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human HP1 alpha/HP1 alpha/CBX5 (NP_001120794.1).
Sequence:MGKK TKRT ADSS SSED EEEY VVEK VLDR RVVK GQVE YLLK WKGF SEEH NTWE PEKN LDCP ELIS EFMK KYKK MKEG ENNK PREK SESN KRKS NFSN SADD
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:HP1; HP1A; HEL25; X5
Positive Sample:HeLa,Jurkat,SH-SY5Y,A-549,MCF7,Mouse brain,293T
Conjugate:Unconjugated
Cellular Localization:Chromosome, Nucleus, centromere.
Calculated MW:22kDa
Observed MW:22kDa

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Purification Method:Affinity purification
Gene ID:23468
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] HP1 alpha/CBX5 Rabbit pAb (CAB12577) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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