Description
CREB3L2 Transcription Factor Activity Assay
The CREB3L2 Transcription Factor Activity Assay Kit is specifically designed for the quantitative measurement of CREB3L2 transcription factor activity in various biological samples. This kit offers high sensitivity and specificity, allowing for precise and reliable results for research purposes.CREB3L2 is a transcription factor that plays a critical role in regulating gene expression, particularly in processes such as cellular growth, differentiation, and stress responses. Dysregulation of CREB3L2 activity has been implicated in various diseases including cancer, metabolic disorders, and neurodegenerative conditions, highlighting its importance as a potential therapeutic target.
The CREB3L2 Transcription Factor Activity Assay Kit provides researchers with a valuable tool for studying the functional role of CREB3L2 in disease pathogenesis and identifying potential drug targets for therapeutic intervention. With its user-friendly protocol and robust performance, this assay kit is a valuable asset for any laboratory conducting molecular biology research.
| Product Name: | CREB3L2 Transcription Factor Activity Assay |
| Product Code: | TFAB00088 |
| Target: | CREB3L2 |
| Synonyms: | BBF2 human homolog on chromosome 7 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie CREB3L2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | CREB3L2: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage. A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS. Belongs to the bZIP family. ATF subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 7q33 Cellular Component: endoplasmic reticulum; nucleoplasm; nucleus Biological Process: cartilage development; chondrocyte differentiation; positive regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q70SY1 |
| NCBI GenInfo Identifier: | 296439387 |
| NCBI Gene ID: | 64764 |
| NCBI Accession: | Q70SY1.3 |
| UniProt Secondary Accession: | Q70SY1,Q6P454, Q6ZMR6, |
| UniProt Related Accession: | Q70SY1 |
| Molecular Weight: | 57kDa |
| NCBI Full Name: | Cyclic AMP-responsive element-binding protein 3-like protein 2 |
| NCBI Synonym Full Names: | cAMP responsive element binding protein 3 like 2 |
| NCBI Official Symbol: | CREB3L2 |
| NCBI Official Synonym Symbols: | BBF2H7 |
| NCBI Protein Information: | cyclic AMP-responsive element-binding protein 3-like protein 2 |
| UniProt Protein Name: | Cyclic AMP-responsive element-binding protein 3-like protein 2 |
| UniProt Synonym Protein Names: | BBF2 human homolog on chromosome 7 |
| Protein Family: | Cyclic AMP-responsive element-binding protein 3-like protein |
| UniProt Gene Name: | CREB3L2 |
