Anti-FABPI Antibody (CAB8895)

SKU:
CAB8895
€129 - €349

Description

Technical Manual

Anti-FABPI Antibody

Product Name:Anti-FABPI Antibody
Product SKU:CAB8895
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human FABPI
Sequence:

Email for sequence

Gene ID:2169
Swiss Prot:P12104
Synonyms:FABPI; I-FABP
Calculated MW:15kDa
Observed MW:14KDa
Reactivity:Mouse, Rat
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry Immunofluorescence 
Positive Samples:Mouse small intestine, Rat small intestine
Cellular Location:

Product Images

Anti-FABPI Antibody (CAB8895)

Western blot - FABPI Rabbit mAb (CAB8895)

Uniprot Information

UniProt Protein Function:FABP2: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 4q28-q31

Cellular Component: cytoplasm

Molecular Function:transporter activity; fatty acid binding

Biological Process: transport; digestion

NCBI Summary:The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]
UniProt Code:P12104
NCBI GenInfo Identifier:119805
NCBI Gene ID:2169
NCBI Accession:P12104.2
UniProt Secondary Accession:P12104,Q2NKJ1,
UniProt Related Accession:P12104
Molecular Weight:132
NCBI Full Name:Fatty acid-binding protein, intestinal
NCBI Synonym Full Names:fatty acid binding protein 2, intestinal
NCBI Official Symbol:FABP2 
NCBI Official Synonym Symbols:FABPI; I-FABP 
NCBI Protein Information:fatty acid-binding protein, intestinal; fatty acid-binding protein 2; intestinal-type fatty acid-binding protein
UniProt Protein Name:Fatty acid-binding protein, intestinal
UniProt Synonym Protein Names:Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP
Protein Family:Fatty acid-binding protein
UniProt Gene Name:FABP2 
UniProt Entry Name:FABPI_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Signal Transduction
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