Fos Transcription Factor Activity Assay

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TFAB00077
€599

Description

ELISA Kit Technical ManualMSDS

Fos Transcription Factor activity assay

Product Description: The ELISA Genie Fos transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates ELISA Genie ELISA kits are designed to significantly reduce experiment Time: and ensure sensitivity and flexibility for high-throughput screening.
Target Synonyms: Cellular oncogene fos;G0/G1 switch regulatory protein 7
Detection Target: Phospho-IRAK1(Thr209)
Reactivity: Human, Mouse, Rat
Pack Size: 12 x 8-Well Microstrips
Detection Method: Colorimetric 450 nm
Format: transcription factor activity assay
Storage and Stability Guarantee: 4°C/6 Months
Sample Type: Nuclear or cell lysates
Range: See Technical Manual
Time: 4.5 hours

Fos Transcription Factor activity assay Protein Information

UniProt Protein Function: Fos: a proto-oncogenic transcription factor of the bZIP family. Dimerizes with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins function as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of FOS has also been associated with apoptotic cell death. Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; transcription factor complex; neuron projection; membrane; endoplasmic reticulum; nucleus; cytosol

Molecular Function:protein binding; double-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; response to gravity; response to cAMP; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; response to toxin; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; female pregnancy; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription factor activity; transforming growth factor beta receptor signaling pathway; conditioned taste aversion; DNA methylation; inflammatory response; toll-like receptor 4 signaling pathway; aging; response to corticosterone stimulus; response to drug; response to light stimulus; nervous system development; MyD88-independent toll-like receptor signaling pathway; sleep; toll-like receptor 2 signaling pathway; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; MyD88-dependent toll-like receptor signaling pathway; response to mechanical stimulus; response to cytokine stimulus; cellular response to extracellular stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to cold; toll-like receptor 9 signaling pathway; response to progesterone stimulus

NCBI Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
UniProt Code: P01100
NCBI GenInfo Identifier: 120470
NCBI Gene ID: 2353
NCBI Accession: P01100.1
UniProt Secondary Accession: P01100,P18849, A8K4E2, B4DQ65,
UniProt Related Accession: P01100
Molecular Weight: 380
NCBI Full Name: Proto-oncogene c-Fos
NCBI Synonym Full Names: FBJ murine osteosarcoma viral oncogene homolog
NCBI Official Symbol: FOS
NCBI Official Synonym Symbols: p55; AP-1; C-FOS
NCBI Protein Information: proto-oncogene c-Fos; activator protein 1; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
UniProt Protein Name: Proto-oncogene c-Fos
UniProt Synonym Protein Names: Cellular oncogene fos; G0/G1 switch regulatory protein 7
Protein Family: Fos-related antigen
UniProt Gene Name: FOS
UniProt Entry Name: FOS_HUMAN
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