Hes1 Rabbit Monoclonal Antibody

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SKU:
CAB0925
€129 - €349

Description

Technical Manual

Hes1 Rabbit Monoclonal Antibody

Product Name:Hes1 Rabbit Monoclonal Antibody
Product SKU:CAB0925
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human Hes1
Sequence:

Email for sequence

Gene ID:3280
Swiss Prot:Q14469
Synonyms:HES-1; HHL; HRY; bHLHb39
Calculated MW:30kDa
Observed MW:30KDa
Reactivity:Mouse, Rat
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry 
Positive Samples:Mouse eye, Rat testis
Cellular Location:

Product Images

Hes1 Rabbit Monoclonal Antibody

Western blot - Hes1 Rabbit mAb (CAB0925)

Uniprot Information

UniProt Protein Function:HES1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 3q28-q29

Cellular Component: nucleoplasm; nucleus

Molecular Function:DNA binding; histone deacetylase binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: artery morphogenesis; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; Notch signaling pathway; positive regulation of astrocyte differentiation; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of JAK-STAT cascade; positive regulation of mitotic cell cycle, embryonic; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; radial glial cell differentiation in the forebrain; STAT protein nuclear translocation; thymus development

NCBI Summary:This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
UniProt Code:Q14469
NCBI GenInfo Identifier:3913825
NCBI Gene ID:3280
NCBI Accession:Q14469.1
UniProt Secondary Accession:Q14469,Q6FHB2,
UniProt Related Accession:Q14469
Molecular Weight:29,541 Da
NCBI Full Name:Transcription factor HES-1
NCBI Synonym Full Names:hes family bHLH transcription factor 1
NCBI Official Symbol:HES1 
NCBI Official Synonym Symbols:HHL; HRY; HES-1; bHLHb39 
NCBI Protein Information:transcription factor HES-1
UniProt Protein Name:Transcription factor HES-1
UniProt Synonym Protein Names:Class B basic helix-loop-helix protein 39; bHLHb39; Hairy and enhancer of split 1; Hairy homolog; Hairy-like protein; hHL
Protein Family:Protein
UniProt Gene Name:HES1 
UniProt Entry Name:HES1_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
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