Description
Human INVS Recombinant Protein (N-GST)
Human INVS Recombinant Protein (N-GST) is a recombinant protein expressed in E. coli, spanning Met1-Lys91, with an N-terminal GST tag. Predicted molecular weight: 36.5 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Inversin (INVS) is a ~117 kDa protein. Required for normal renal development and establishment of left-right axis. For research use only.
Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8.
| Product Name: | Human INVS Recombinant Protein (N-GST) |
| SKU: | GXRP03106 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | INV, INVS, Inversin, Inversion of embryo turning homolog, NPHP2, Nephrocystin-2 |
| Tag: | N-GST |
| Expression Host: | E. coli |
| Protein Length: | Met1-Lys91 |
| Calculated MW: | 36.5 kDa |
| UniProt: | Q9Y283 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
