Description
IKZF4 Transcription Factor Activity Assay
The IKZF4 Transcription Factor Activity Assay provided by AssayGenie is a cutting-edge kit designed for accurate measurement of IKZF4 transcription factor activity in cell lysates. This assay kit offers high sensitivity and specificity, ensuring precise and reliable results for research applications.IKZF4, also known as Ikaros Family Zinc Finger 4, plays a crucial role in regulating gene expression and is involved in various cellular processes such as immune response, hematopoiesis, and differentiation. Dysregulation of IKZF4 has been linked to several diseases including leukemia, autoimmune disorders, and inflammatory conditions, making it a valuable target for research and drug development.
With the IKZF4 Transcription Factor Activity Assay, researchers can assess IKZF4 activity in a simple and efficient manner, allowing for in-depth analysis of its role in disease pathogenesis and potential therapeutic interventions. Trust AssayGenie for high-quality assays that enable groundbreaking discoveries in the field of molecular biology.
| Product Name: | IKZF4 Transcription Factor Activity Assay |
| Product Code: | TFAB00203 |
| Target: | IKZF4 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie IKZF4 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | IKZF4: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Belongs to the Ikaros C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 12q13 Cellular Component: nucleus Molecular Function:protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; bHLH transcription factor binding; transcription factor activity Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002] |
| UniProt Code: | Q9H2S9 |
| NCBI GenInfo Identifier: | 122891864 |
| NCBI Gene ID: | 64375 |
| NCBI Accession: | NP_071910.3 |
| UniProt Related Accession: | Q9H2S9 |
| Molecular Weight: | |
| NCBI Full Name: | zinc finger protein Eos isoform a |
| NCBI Synonym Full Names: | IKAROS family zinc finger 4 |
| NCBI Official Symbol: | IKZF4 |
| NCBI Official Synonym Symbols: | EOS; ZNFN1A4 |
| NCBI Protein Information: | zinc finger protein Eos |
| UniProt Protein Name: | Zinc finger protein Eos |
| UniProt Synonym Protein Names: | Ikaros family zinc finger protein 4 |
| Protein Family: | Eosinophil peroxidase |
| UniProt Gene Name: | IKZF4 |
| UniProt Entry Name: | IKZF4_HUMAN |
