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[KO Validated] NCOA2 Rabbit Polyclonal Antibody (CAB10280)

SKU:
CAB10280
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • KO Validated Antibodies 1 Anti-NCOA2 Antibody CAB10280KO Validated
  • KO Validated Antibodies 1 Anti-NCOA2 Antibody CAB10280KO Validated
  • KO Validated Antibodies 1 Anti-NCOA2 Antibody CAB10280KO Validated
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] NCOA2 Rabbit Polyclonal Antibody
SKU:CAB10280
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 550-820 of human NCOA2 (NP_006531.1).
Sequence:SSLA SPDL KMGN LQNS PVNM NPPP LSKM GSLD SKDC FGLY GEPS EGTT GQAE SSCH PGEQ KETN DPNL PPAV SSER ADGQ SRLH DSKG QTKL LQLL TTKS DQME PSPL ASSL SDTN KDST GSLP GSGS THGT SLKE KHKI LHRL LQDS SSPV DLAK LTAE ATGK DLSQ ESSS TAPG SEVT IKQE PVSP KKKE NALL RYLL DKDD TKDI GLPE ITPK LERL DSKT DPAS NTKL IAMK TEKE EMSF EPGD QPGS ELDN LEEI LDDL QNSQ LPQ
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:SRC2; TIF2; GRIP1; KAT13C; NCoA-2; bHLHe75; A2
Positive Sample:293T,BT-474
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:159kDa
Observed MW:200kDa

The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:10499
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and NCOA2 knockout (KO) 293T cells, using [KO Validated] NCOA2 Rabbit pAb (CAB10280) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.

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