The Munc 13-1 Polyclonal Antibody is a valuable tool for researchers studying Munc 13-1, a protein involved in synaptic vesicle priming and neurotransmitter release. This antibody, produced through immunization of rabbits, is highly specific and reacts strongly with human samples. Validated for use in Western blotting applications, it allows for the detection and analysis of Munc 13-1 in various cell types, making it an essential asset for studies in neuroscience and neurobiology.Munc 13-1 is a key player in the regulation of synaptic transmission and neurotransmitter release, essential processes for proper brain function and communication between neurons.
Dysregulation of Munc 13-1 has been implicated in various neurological disorders, making it a promising target for therapeutic interventions. By studying the function and regulation of Munc 13-1, researchers can gain valuable insights into the mechanisms underlying neurological diseases and potentially develop novel treatment strategies.
Product Name:
Munc 13-1 Polyclonal Antibody
SKU:
CAB22550
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant protein of human Munc 13-1.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:1000 - 1:5000
Synonyms:
Munc13-1; Munc 13-1
Positive Sample:
Mouse brain,Rat brain
Cellular Localization:
neuromuscular junction, neuron projection, plasma membrane, presynaptic active zone, presynaptic active zone cytoplasmic component, presynaptic membrane, synaptic vesicle membrane, terminal bouton
Calculated MW:
193kDa
Observed MW:
220kDa
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis.
Purification Method:
Affinity purification
Gene ID:
23025
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Munc 13-1 antibody (CAB22550) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
