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Anti-PABPN1 Antibody (CAB1735)

SKU:
CAB1735
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Polyclonal AntibodyPN1 Rabbit Monoclonal Antibody
Antibody SKU:CAB1735
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PABPN1
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, Raji, Mouse lung, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human PABPN1
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8106
Uniprot:Q86U42
Cellular Location:
Calculated MW:49kDa
Observed MW:50KDa
Anti-PABPN1 Rabbit Monoclonal Antibody (CAB1735)Western blot - PABPN1 Rabbit mAb (CAB1735)
Synonyms:OPMD, PAB2, PABII, PABP-2, PABP2
Background:This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q86U42
NCBI GenInfo Identifier:46403176
NCBI Gene ID:8106
NCBI Accession:Q86U42.3
UniProt Secondary Accession:Q86U42,O43484, D3DS49,
UniProt Related Accession:Q86U42
Molecular Weight:306
NCBI Full Name:Polyadenylate-binding protein 2
NCBI Synonym Full Names:poly(A) binding protein, nuclear 1
NCBI Official Symbol:PABPN1  
NCBI Official Synonym Symbols:OPMD; PAB2; PABII; PABP2; PABP-2  
NCBI Protein Information:polyadenylate-binding protein 2; poly(A) binding protein 2; poly(A) binding protein II
UniProt Protein Name:Polyadenylate-binding protein 2
UniProt Synonym Protein Names:Nuclear poly(A)-binding protein 1; Poly(A)-binding protein II; PABII; Polyadenylate-binding nuclear protein 1
UniProt Gene Name:PABPN1  
UniProt Entry Name:PABP2_HUMAN

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