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PE/Cyanine5 Anti-Human CD28 Antibody [CD28.2] (AGEL2370)

Datasheet MSDS
SKU AGEL2370
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG1, κ
Clone CD28.2
Conjugation PE/Cyanine5
€113 - €495

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Description

system_update_altDatasheetsystem_update_altMSDS

PE/Cyanine5 Anti-Human CD28 Antibody [CD28.2]

The PE-Cyanine5 Anti-Human CD28 Antibody (CD28-2) offered by Assaygenie is a vital tool for researchers studying the CD28 protein, a key co-stimulatory molecule essential for T cell activation. This antibody, derived from rabbits, exhibits high specificity and sensitivity when used in flow cytometry and immunofluorescence applications, allowing for precise detection and analysis of CD28 expression on human cells.CD28 plays a crucial role in T cell activation, providing the second signal necessary for optimal immune response. Understanding the function and regulation of CD28 is fundamental in the fields of immunology, infectious disease, and autoimmunity research.

The PE-Cyanine5 Anti-Human CD28 Antibody (CD28-2) aids in uncovering the intricate mechanisms governing T cell activation, offering valuable insights into potential therapeutic strategies for immune-related disorders.With its reliable performance and versatility in various experimental settings, the PE-Cyanine5 Anti-Human CD28 Antibody (CD28-2) is an essential tool for researchers seeking to deepen their understanding of immune responses and develop innovative treatments for a range of diseases. Trust Assaygenie's high-quality antibody to deliver accurate and reproducible results for your research endeavors.

Product Title:PE/Cyanine5 Anti-Human CD28 Antibody [CD28.2]
SKU:AGEL2370
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CD28.2
Synonyms:PAS2;MNS;HGpMiX;GYPA;GPSAT;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P10747
Gene ID:940
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
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