The PE-GenieFluor 594 Anti-Human CD28 Antibody (CD28-2) offered by AssayGenie is a cutting-edge tool designed for researchers studying the CD28 cell surface molecule, a key regulator of T cell activation and immune responses. This antibody, specifically designed for use in flow cytometry applications, recognizes human CD28 with high specificity and sensitivity.CD28 is a co-stimulatory molecule essential for T cell activation and proliferation. It plays a crucial role in shaping the adaptive immune response by providing the second signal necessary for full T cell activation alongside the T cell receptor signal. Research into CD28 function is vital for understanding immune responses, immune tolerance, and developing therapeutic strategies targeting T cell activation in various diseases.
The PE-GenieFluor 594 Anti-Human CD28 Antibody (CD28-2) from AssayGenie offers researchers a reliable and effective tool for investigating the expression and function of CD28 in various cell types and conditions. Its high specificity and performance in flow cytometry make it an invaluable asset for studies in immunology, cancer research, and autoimmune disorders. Gain precise insights into CD28 expression and function with the PE-GenieFluor 594 Anti-Human CD28 Antibody (CD28-2) from AssayGenie.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P10747
Gene ID:
940
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
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