Anti-C8orf4 Antibody (CAB6241)

Antibody Name:	Anti-C8orf4 Antibody
Antibody SKU:	CAB6241
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-106 of human C8orf4 (NP_064515.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MKAK RSHQ AIIM STSL RVSP SIHG YHFD TASR KKAV GNIF ENTD QESL ERLF RNSG DKKA EERA KIIF AIDQ DVEE KTRA LMAL KKRT KDKL FQFL KLRK YSIK VH
Gene ID:	56892
Uniprot:	Q9NR00
Cellular Location:	Cytoplasm, Nucleus, Nucleus speckle, nucleolus
Calculated MW:	12kDa
Observed MW:	Refer to figures

Synonyms:

C8orf4, TC-1, TC1

Background:

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.

UniProt Protein Function:	C8orf4: May decrease apoptosis.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 8p11.2 Biological Process: apoptosis
NCBI Summary:	This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
UniProt Code:	Q9NR00
NCBI GenInfo Identifier:	296434443
NCBI Gene ID:	56892
NCBI Accession:	Q9NR00.2
UniProt Related Accession:	Q9NR00
Molecular Weight:	106
NCBI Full Name:	Uncharacterized protein C8orf4
NCBI Synonym Full Names:	chromosome 8 open reading frame 4
NCBI Official Symbol:	C8orf4
NCBI Official Synonym Symbols:	TC1; TC-1
NCBI Protein Information:	uncharacterized protein C8orf4; human thyroid cancer 1; thyroid cancer protein 1
UniProt Protein Name:	Uncharacterized protein C8orf4
UniProt Synonym Protein Names:	Thyroid cancer protein 1; TC-1
Protein Family:	Protein
UniProt Gene Name:	C8orf4
UniProt Entry Name:	CH004_HUMAN

	Immunohistochemistry of paraffin-embedded rat lung using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse lung using C8orf4 antibody (CAB6241) at dilution of 1:100 (40x lens).

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)