The Recombinant Chk2 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C333332) against Chk2. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. Produced by recombinant technology in Rabbit hosts and purified by affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB applications. It has been validated by WB analysis of Jurkat. The target is localized to the nucleus, nucleus, Isoform 10 is present throughout the cell and Nucleus>PML body, nucleus>nucleoplasm, Recruited into PML bodies together with TP53.
Product Name:
Recombinant Chk2 Monoclonal Antibody
SKU:
AGEL8637
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
CDS 1, Cds1, Cds1 homolog, Checkpoint kinase 2, Checkpoint like protein CHK2, CHEK 2, Chek2, Chk 2, CHK2, CHK2 checkpoint homolog, CHK2 checkpoint homolog (S. pombe), hCds1, HuCds 1, LFS 2, LFS2, PP1425, RAD 53, RAD53, Rad53 homolog, Ser, Serine/threonine protein kinase Chk2, Serine/threonine-protein kinase Chk2
