The Recombinant Pan Trk Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C421592) against Pan Trk. The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. Neurotrophin signaling through these receptors regulates a number of physiological processes, such as cell survival, proliferation, neural development, and axon and dendrite growth and patterning. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Mouse and Rat samples.
This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of Mouse brain, Rat brain and IHC analysis of Mouse cerebral cortex. The target is localized to the cytoplasm, membrane.
