The Recombinant Trk A Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C110910) against Trk A. This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human, Mouse and Rat samples.
This antibody is suitable for WB, IHC, IF, IP and ELISA applications. It has been validated by IHC analysis of Human brain. The target is localized to the cell membrane, Single-pass type I membrane protein, early endosome membrane, Single-pass type I membrane protein, late endosome membrane, Single-pass type I membrane protein, recycling endosome membrane, Single-pass type I membrane protein, Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes.
Product Name:
Recombinant Trk A Monoclonal Antibody
SKU:
AGEL6216
Size:
50 µL, 100 µL
Antibody Type:
Recombinant Monoclonal Antibody
Synonyms:
gp140trk, High affinity nerve growth factor receptor, High affinity nerve growth factor receptor precursor, MTC, Neurotrophic tyrosine kinase receptor type 1, NTRK, NTRK1, Oncogene TRK, p14-TrkA, p140 TrkA, p140-TrkA, Slow nerve growth, TRK, Trk A, Trk-A, TRK1, TRK1-transforming tyrosine kinase protein, TRKA, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A
Reactivity:
Human, Mouse, Rat
Immunogen:
Recombinant Human Trk A protein
Applications:
WBIHCIFIPELISA
Clonality:
Recombinant Monoclonal
Clone No:
C110910
Host:
Rabbit
Isotype:
Rabbit IgG
Target:
Trk A
Conjugation:
Unconjugated
Recommended Dilution:
IHC 1:2000-10000; WB 1:2000-10000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
UniProt:
P04629
Purification:
Protein A
Concentration:
0.2 mg/mL
Buffer:
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:
Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
![Anti-Trk A [R06-2B8] Monoclonal Antibody (AGMB01755)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/273044/679659/anti-trk-a-r06-2b8-monoclonal-antibody-agmb01755__68901.1773039624.jpg?c=2 "Anti-Trk A [R06-2B8] Monoclonal Antibody (AGMB01755)")
