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Galegenimab: Unlocking the Potential of Anti-CD47 in Cancer Research(Post)
Quick Facts About GalegenimabWhat is Galegenimab?Galegenimab is an anti-CD47 monoclonal antibody designed to block the "don't eat me" signal, enhancing the immune system's ability to eli
CIDE: The New Bioinformatics Engine Unmasking Secreted Proteins for Precision Immunotherapy(Post)For decades, the battle against cancer has focused on the cellular 'soldiers' and the genetic 'blueprints' within them. Yet, a vast, invisible world of communication exists between these cells—a secr
Immunophenotyping by Flow Cytometry and Cell Type Markers(Post)Immunophenotyping by Flow Cytometry Immunophenotyping is a technique used in the field of immunology and cell biology to identify and classify cells based on the specific proteins o
Navigating the Intricacies of Intracellular Flow Cytometry: Key Considerations(Post)In the evolving landscape of cellular biology, intracellular flow cytometry (ICFC) stands out as a powerful technique for analyzing the complexities within cells. This advanced method extends the
Osteoimmunology: The RANKL-OPG Axis & Bone Erosion(Page) Cell Death Pathways: Intrinsic vs Extrinsic Apoptosis Guide(Post)At Assay Genie we have created a comprehensive guide outlining everything you need to know about apoptosis! Key Takeaways: Apoptosis is a programmed cell death process, vital for tissue
Breakthrough Discovery: Epstein-Barr Virus Identified as Primary Trigger for Lupus(Post)Breakthrough Discovery: Epstein-Barr Virus Identified as Primary Trigger for Lupus A groundbreaking study published in November 2025 has provided the most definitive evidence to date that the common E
One Ligand, Two Receptors, Opposite Jobs: TNFR1 vs TNFR2(Post)Blocking TNF cures rheumatoid arthritis in some patients and triggers demyelination in others. That is not a dosing problem, and it is not a patient-selection problem. It is the direct consequence of
What Causes Acute Pancreatitis?(Post)Acute pancreatitis (AP) is a condition in which activated enzymes and inflammatory mediators released from the pancreas cause damage to the pancreas and surrounding tissues. AP is furt
Neural Stem Cell Differentiation: Pathways and Lineage-Specific Markers(Post)Understanding the differentiation pathways of neural stem cells (NSCs) and the identification of lineage-specific markers is a cornerstone in the field of neurobiology and regenerative medicine. T
Necrosis: Types, Causes, Symptoms & Prevention Guide(Post)Cell Biology · PathologyNecrosis: Types, Causes, Mechanisms and How It Is MeasuredNecrosis is cell death accompanied by membrane rupture and release of intracellular contents — which is what makes it
FoxP3: Understanding Regulatory T Cell Control in Tumor Immunity(Post)Introduction to FoxP3 and Regulatory T Cells in CancerFoxP3 (forkhead box P3) is a transcription factor critical for the development and function of regulatory T cells (Tregs), a speciali
T-Cell Engagers: Signal 1 Without Signal 2(Post)A T-cell engager does not give the T cell an instruction. It gives it an address. A bispecific antibody with one arm on CD3 and the other on a tumour antigen forces two membranes into contact and let
Innate Lymphoid Cells: ILC1, ILC2 & ILC3(Page) Anti-PD-1: Restoring T Cell Function in Cancer Immunotherapy(Post)Cancer immunotherapy has revolutionized the treatment landscape for various malignancies. One of the most promising therapeutic strategies is the use of immune checkpoint inhibitors, part
TIM-3: Targeting T Cell Exhaustion for Better Immunotherapy Outcomes(Post)T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to ef
Wnt Signalling Pathway in Immunity(Post)What is Wnt Signalling? The Wnt signalling pathway is an evolutionarily conserved pathway that plays critical roles in the regulation of determining cell fate, polari
Apoptosis Caspase Pathways: A Closer Look at Cellular Suicide(Post)Apoptosis, or programmed cell death, is a fundamental process that plays a critical role in the development and maintenance of healthy tissues. Central to this process are caspases, a family of cy
Eosinophils, IL-5 and the Type 2 Granulocyte Axis(Page) Microglial Functions Explained: Immunity, Inflammation & Neurodegeneration(Post)Neuroscience · NeuroimmunologyMicroglial Functions: Immunity, Inflammation & NeurodegenerationMicroglia are the resident immune cells of the central nervous system — dynamic sentinels that survey the